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Key Documents

SRP0438

Sigma-Aldrich

TDP2 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥87% (SDS-PAGE)

Synonym(s):

EAP2, TTRAP, tyrosyl-DNA phosphodiesterase 2

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥87% (SDS-PAGE)

form

aqueous solution

mol wt

67 kDa

packaging

pkg of 20 μg

NCBI accession no.

NM_016614

UniProt accession no.

O95551

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TDP2(51567)

General description

Human tyrosyl DNA phosphodiesterase 2, or TDP2 (GenBank Accession No. NM_016614) full length with N-terminal His-GST-tag, MW = 67 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Physical form

Formulated in 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, 20% Glycerol, and 3 mM DTT.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
Christophe Marchand et al.
Molecular cancer therapeutics, 13(8), 2116-2126 (2014-07-16)
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminator-induced DNA

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