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U6758

Sigma-Aldrich

UCL 2077

≥98% (HPLC), solid

Synonym(s):

(3-Triphenylmethylaminomethyl)pyridine

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About This Item

Empirical Formula (Hill Notation):
C25H22N2
CAS Number:
918311-87-2
Molecular Weight:
350.46
MDL number:
MFCD00585879
UNSPSC Code:
12352200
PubChem Substance ID:
329827644
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >20 mg/mL
H2O: insoluble

SMILES string

C(NC(c1ccccc1)(c2ccccc2)c3ccccc3)c4cccnc4

InChI

1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2

InChI key

PQFNWDHABGBCHB-UHFFFAOYSA-N

Application

UCL 2077 has been used for slow afterhyperpolarization (sAHP) studies in thalamic paraventricular nucleus (PVT) neurons. UCL 2077 has also been used for studying its effects on the increase in excitability of hippocampal pyramidal cells.

Biochem/physiol Actions

UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker.

Preparation Note

UCL 2077 is soluble in DMSO at a concentration >20 mg/ml and is insoluble in water.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mala M Shah et al.
Molecular pharmacology, 70(5), 1494-1502 (2006-08-01)
The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not been explicitly tested for 2 reasons: 1) there are, at present, no
Li Zhang et al.
Journal of neurophysiology, 104(4), 2052-2062 (2010-08-20)
Thalamic paraventricular nucleus (PVT) neurons exhibit a postburst apamin-resistant slow afterhyperpolarization (sAHP) that is unique to midline thalamus, displays activity dependence, and is abolished in tetrodotoxin. Analysis of the underlying sI(AHP) confirmed a requirement for Ca(2+) influx with contributions from
Hung-Te Hsu et al.
International journal of molecular sciences, 21(4) (2020-02-26)
UCL-2077 (triphenylmethylaminomethyl)pyridine) was previously reported to suppress slow afterhyperpolarization in neurons. However, the information with respect to the effects of UCL-2077 on ionic currents is quite scarce. The addition of UCL-2077 decreased the amplitude of erg-mediated K+ current (IK(erg)) together
James D Angstadt et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 203(8), 613-633 (2017-05-13)
Postinhibitory rebound (PIR) responses in leech dorsal excitatory motor neurons (cell DE-3) are eliminated by Ca

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