440744
Polycaprolactone
average Mn 80,000
Synonym(s):
2-Oxepanone homopolymer, 6-Caprolactone polymer
About This Item
form
pellets (~3 mm)
Quality Level
mol wt
average Mn 80,000
impurities
<0.5% water
mp
60 °C (lit.)
density
1.145 g/mL at 25 °C
Mw/Mn
<2
application(s)
3D bioprinting
advanced drug delivery
SMILES string
C1CCC(=O)OCC1 (Canonical-SMILES)
InChI
1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2
InChI key
PAPBSGBWRJIAAV-UHFFFAOYSA-N
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General description
- It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
- Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.
Application
- PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
- Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
- PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
- Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
- Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.
Features and Benefits
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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