Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

83060

Sigma-Aldrich

tert-Butyl 12-amino-4,7,10-trioxadodecanoate

technical, ≥80% (T)

Synonym(s):

Amino-PEG3-tert-butyl ester, tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C13H27NO5
CAS Number:
252881-74-6
Molecular Weight:
277.36
MDL number:
MFCD06201017
UNSPSC Code:
12352200
PubChem Substance ID:
57652942
NACRES:
NA.22

grade

technical

Quality Level

100

Assay

≥80% (T)

form

solid

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

SMILES string

CC(C)(C)OC(=O)CCOCCOCCOCCN

InChI

1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3

InChI key

CWFSAZJIJBTKRC-UHFFFAOYSA-N

Application

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:
  • Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
  • Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
  • Synthesis of polycationic adamantane-based dendrons for cell imaging.
  • Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

Other Notes

Intermediate in the synthesis of a spacer for combinatorial chemistry

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

337.5 °F

Flash Point(C)

169.7 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCBW2535
BCBM5598V
BCBK2255V
BCBD2137V
BCBB8779

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Phthalocyanine?peptide conjugates for epidermal growth factor receptor targeting.
Ongarora B G, et al.
Journal of Medicinal Chemistry, 55(8), 3725-3738 (2012)
Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor?Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope.
Keil S, et al.
Angewandte Chemie (International Edition in English), 40(2), 366-369 (2001)
Polycationic adamantane-based dendrons of different generations display high cellular uptake without triggering cytotoxicity.
Grillaud M, et al.
Journal of the American Chemical Society, 136(2), 810-819 (2014)
Water soluble SERS labels comprising a SAM with dual spacers for controlled bioconjugation.
Jehn C, et al.
Physical Chemistry Chemical Physics, 11(34), 7499-7504 (2009)
Angewandte Chemie (International Edition in English), 113, 379-379 (2001)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service