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Sigma-Aldrich

Acetonitrile solution

suitable for HPLC, contains 10.0% acetone, 40.0% 2-propanol, 0.05% formic acid

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein:
4124158
MDL number:
UNSPSC Code:
12190000
PubChem Substance ID:

product name

Acetonitrile solution, contains 10.0% acetone, 0.05% formic acid, 40.0% 2-propanol

vapor density

1.41 (vs air)

Quality Level

vapor pressure

72.8 mmHg

form

liquid

contains

0.05% formic acid
10.0% acetone
40.0% 2-propanol

expl. lim.

8 %

technique(s)

HPLC: suitable

bp

81-82 °C

mp

-48 °C

density

0.782 g/mL at 25 °C

application(s)

food and beverages

format

mixture

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

The product is an acetonitrile solution containing 40.0% 2-propanol, 0.05% formic acid, 10.0% acetone. This pre-blended solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Acetonitrile (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength.

Application


  • Preparation and characterization of stationary phase gradients on C8 liquid chromatography columns.: This research discusses the preparation of stationary phase gradients on C8 columns using acetonitrile solutions, enhancing chromatographic resolution and efficiency, pivotal for the analytical chemistry field (Cecil et al., 2024).

  • Metal-cation-induced shifts in thiolate redox and reduced sulfur speciation.: Highlighting a study on the redox behavior of thiolates influenced by metal cations, where acetonitrile solutions were crucial for maintaining reaction environments, crucial for developing new catalytic and sensor applications (Seo et al., 2024).

  • A Phosphine-Oxide Cobalt(II) Complex and Its Catalytic Activity Studies toward Alcohol Dehydrogenation Triggered Direct Synthesis of Imines and Quinolines.: This paper presents the synthesis of a novel cobalt(II) complex using acetonitrile solution, which showed significant catalytic activity in synthesizing bioactive molecules, illustrating the solvent′s role in facilitating complex chemical reactions (Khatua et al., 2024).

  • [Simultaneous determination of 31 banned veterinary drugs during egg-laying period in poultry eggs by ultra performance liquid chromatography-tandem mass spectrometry].: Demonstrating the use of acetonitrile solutions in sample preparation for high-throughput UPLC-MS/MS analysis, this study significantly contributes to food safety and drug residue analysis (Zhu et al., 2024).

  • Probing Isolated Water Molecules in Aqueous Acetonitrile Solutions Using Oxygen K-Edge X-ray Absorption Spectroscopy.: This research utilizes acetonitrile solutions to study the interaction of water molecules at the molecular level, providing insights critical for understanding solvation dynamics and mixture behaviors (Nagasaka, 2024).

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

14.0 - 23.0 °F - closed cup

Flash Point(C)

-10 - -5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)
Acetonitrile, the polarity chameleon.
Zarzycki PK, et al.
Analytical and Bioanalytical Chemistry, 397(3), 905-908 (2010)
Ranen Aviner et al.
PLoS genetics, 11(10), e1005554-e1005554 (2015-10-07)
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest pervasive regulation of post-transcriptional steps and support the
Seung-Ho Shin et al.
PloS one, 10(9), e0137011-e0137011 (2015-09-04)
Congenital cholesteatomas are epithelial lesions that present as an epithelial pearl behind an intact eardrum. Congenital and acquired cholesteatomas progress quite differently from each other and progress patterns can provide clues about the unique origin and pathogenesis of the abnormality.
Fang Xu et al.
The Plant cell, 27(5), 1547-1562 (2015-05-15)
Nod-like receptors (NLRs) serve as immune receptors in plants and animals. The stability of NLRs is tightly regulated, though its mechanism is not well understood. Here, we show the crucial impact of N-terminal acetylation on the turnover of one plant

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