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40234

Sigma-Aldrich

N,N-Dimethyldodecylamine N-oxide

BioXtra, ≥99.0% (NT)

Synonym(s):

DDAO, LDAO, Lauryldimethylamine N-oxide

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About This Item

Linear Formula:
CH3(CH2)11N(O)(CH3)2
CAS Number:
Molecular Weight:
229.40
Beilstein:
1769927
EC Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.26

description

non-ionic

Quality Level

product line

BioXtra

Assay

≥99.0% (NT)

form

powder

mol wt

229.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.03% peroxides (as H2O2)

CMC

1-2 mM

mp

132-133 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤100 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCC[N+](C)(C)[O-]

InChI

1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

InChI key

SYELZBGXAIXKHU-UHFFFAOYSA-N

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General description

N,N-Dimethyldodecylamine N-oxide is a non-denaturing zwitterionic surfactant with a critical micelle concentration (CMC) of approximately 1 mM. It is used to solubilize proteins and to study the conformation and molecular interactions of macromolecules.

Application

N,N-Dimethyldodecylamine N-oxide has been used in the cell lysis and resuspension of cell pellets for western blot analysis.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiaoyi Deng et al.
Journal of medicinal chemistry, 57(12), 5381-5394 (2014-05-08)
Malaria is one of the most serious global infectious diseases. The pyrimidine biosynthetic enzyme Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) is an important target for antimalarial chemotherapy. We describe a detailed analysis of protein-ligand interactions between DHODH and a triazolopyrimidine-based inhibitor
Vasyl Bondarenko et al.
Biochimica et biophysica acta, 1818(5), 1261-1268 (2012-03-01)
The α4β2 nicotinic acetylcholine receptor (nAChR) is the predominant heteromeric subtype of nAChRs in the brain, which has been implicated in numerous neurological conditions. The structural information specifically for the α4β2 and other neuronal nAChRs is presently limited. In this
Doru Constantin et al.
Physical review letters, 101(9), 098101-098101 (2008-10-15)
We study by synchrotron small-angle x-ray scattering highly aligned lamellar phases of a zwitterionic surfactant, doped with monodisperse and spherical hydrophobic inorganic particles as a function of particle concentration. Analysis of the structure factor of the two-dimensional fluid formed by
Christian D Lorenz et al.
Langmuir : the ACS journal of surfaces and colloids, 27(2), 546-553 (2010-12-21)
A series of large-scale atomistic molecular dynamics simulations were conducted to study the structural and interfacial properties of nonionic dimethyldodecylamine-N-oxide (DDAO) micelles with an aggregation number of 104 in pure water, which was determined using small-angle neutron scattering (SANS). From
Hiroki Konno et al.
The EMBO journal, 25(19), 4596-4604 (2006-09-16)
The chloroplast-type F(1) ATPase is the key enzyme of energy conversion in chloroplasts, and is regulated by the endogenous inhibitor epsilon, tightly bound ADP, the membrane potential and the redox state of the gamma subunit. In order to understand the

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