F8682

Fosmidomycin sodium salt hydrate

≥95% (NMR)

• Synonym(s): (3-(Formylhydroxyamino)propyl)phosphonic acid sodium salt, (3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt, FR 31564
• Empirical Formula (Hill Notation): C₄H₁₀NO₅P · xNa⁺ · yH₂O
• CAS Number: 66508-53-0
• Molecular Weight: 183.10 (anhydrous free acid basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥95% (NMR)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10)
• InChI key: GJXWDTUCERCKIX-UHFFFAOYSA-N

Description

Application

Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.

Biochem/physiol Actions

Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable