K3250
Kynuramine dihydrobromide
monoamine oxidase substrate, fluorogenic, ≥97% (TLC), crystalline
Synonym(s):
3-(2-Aminophenyl)-3-oxopropanamine
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About This Item
Empirical Formula (Hill Notation):
C9H12N2O · 2HBr
CAS Number:
Molecular Weight:
326.03
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
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Product Name
Kynuramine dihydrobromide, crystalline
Assay
≥97% (TLC)
Quality Level
form
crystalline
solubility
water: 50 mg/mL, clear to slightly hazy
storage temp.
−20°C
SMILES string
Br.NCCC(=O)c1ccccc1N
InChI
1S/C9H12N2O.BrH/c10-6-5-9(12)7-3-1-2-4-8(7)11;/h1-4H,5-6,10-11H2;1H
InChI key
YUPVVZSYBUIDQR-UHFFFAOYSA-N
Application
Kynuramine dihydrobromide has been used as a substrate for monoamine oxidase.
Biochem/physiol Actions
Kynuramine dihydrobromide is a substrate for the enzyme monoamine oxidase. The end product is the formation of fluorescence detectable 4-hydroxyquinoline (4-HOQ) measured in a fluorescence spectrophotometer at 380 nm.
Substrates
Substrate for monoamine oxidase
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Magdalena S Nel et al.
Bioorganic chemistry, 69, 20-28 (2016-09-24)
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related to series of heterocyclic chalcone derivatives which have previously been
Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system
Li G, et al.
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Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parr
Berntssen MHG, et al.
Aquatic Toxicology (Amsterdam, Netherlands), 65(1), 55-72 (2003)
Zhanna V Chirkova et al.
Drug development research, 79(2), 81-93 (2018-03-24)
Hit, Lead & Candidate Discovery In recent studies, we have shown that pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and to further derive structure-activity relationships
M Figueiredo-González et al.
Food research international (Ottawa, Ont.), 106, 558-567 (2018-03-28)
In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive
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