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L4129

Sigma-Aldrich

L-α-Lysophosphatidylcholine from egg yolk

≥99%, Type I, powder

Synonym(s):

1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

egg yolk

Quality Level

description

zwitterionic

type

Type I

Assay

≥99%

form

powder

color

white

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

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Application

L-α-Lysophosphatidylcholine from egg yolk has been used:
  • as a surfactant
  • as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
  • as a demyelinating agent for nerve
  • as a component in sperm nuclei preparation buffer

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Quality

Contains primarily palmitic and stearic acids.

Preparation Note

Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Director configurations in nematic droplets with inhomogeneous boundary conditions
Prishchepa OO, et al.
Physical review. E, 72(3), 031712-031712 (2005)
Alan Brito Carneiro et al.
PloS one, 8(9), e76233-e76233 (2013-12-07)
Lysophosphatidylcholine (LPC) is the main phospholipid component of oxidized low-density lipoprotein (oxLDL) and is usually noted as a marker of several human diseases, such as atherosclerosis, cancer and diabetes. Some studies suggest that oxLDL modulates Toll-like receptor (TLR) signaling. However
Transplantation of human skin microbiota in models of atopic dermatitis
Myles IA, et al.
JCI insight, 1(10), 031712-031712 (2016)
N Farrow et al.
Scientific reports, 3, 1287-1287 (2013-02-16)
Genetic therapies for cystic fibrosis (CF) must be assessed for safety and efficacy, so testing in a non-human primate (NHP) model is invaluable. In this pilot study we determined if the conducting airways of marmosets (n = 2) could be
RP-CARS: label-free optical readout of the myelin intrinsic healthiness
de Vito G, et al.
Optics Express, 22(11), 13733-13743 (2014)

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