P0483
Anti-Potassium Channel SK2 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Apamin-Sensitive Conductance Ca2+-Dependent K+ Channel, KCa2, Kcnn2, SKCa2
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About This Item
conjugate:
unconjugated
application:
WB CL
clone:
polyclonal
species reactivity:
human, rat
citations:
17
technique(s):
western blot (chemiluminescent): 1:200 using rat brain membranes
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, rat
technique(s)
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Kcnn2(54262)
General description
Potassium calcium-activated channel subfamily N member 2 (KCNN2) or SK2 is expressed in rat Purkinje cells. The gene encoding this protein is localized on rat chromosome 18q11.
Immunogen
synthetic peptide corresponding to amino acids 542-559 of rat potassium channel SK2.
Application
Anti-Potassium Channel SK2 (Apamin-Sensitive Conductance Ca2+-Dependent K+ Channel, KCa2, Kcnn2, SKCa2) antibody produced in rabbit has been used for immunohistochemistry and immunofluorescence.
Biochem/physiol Actions
Potassium calcium-activated channel subfamily N member 2 (KCNN2) or SK2 has a role in the modulation of intrinsic excitability of neurons and Purkinje cells. It also has a role in synaptic transmission and plasticity. SK2 promotes hippocampus-dependent learning and memory in the mammalian brain.
Physical form
Lyophilized at 0.3-1.4 mg/mL from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% - 0.050% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Low-Level Vagus Nerve Stimulation Upregulates Small Conductance Calcium Activated Potassium Channels in the Stellate Ganglion
Mark J. Shen
Heart Rhythm : the Official Journal of the Heart Rhythm Society (2013)
SK2 channel expression and function in cerebellar Purkinje cells
Eric Hosy
The Journal of Physiology (2011)
Neurotransmitter modulation of small conductance Ca2+-activated K+ (SK) channels by regulation of Ca2+ gating
Francois M
Neuron (2008)
Jing-Yi Jeng et al.
The Journal of physiology, 598(18), 3891-3910 (2020-07-02)
Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurring in the auditory sensory cells, including those associated with the
Eleonora Katz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(36), 7814-7820 (2004-09-10)
In the mature cochlea, inner hair cells (IHCs) transduce acoustic signals into receptor potentials, communicating to the brain by synaptic contacts with afferent fibers. Before the onset of hearing, a transient efferent innervation is found on IHCs, mediated by a
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