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Key Documents

SAB2900202

Sigma-Aldrich

Anti-CX3CR1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

beta chemokine receptor-like 1, chemokine c-x3-c receptor 1, cmkbrl1, cmkdr1, fkn receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt accession no.

P49238

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CX3CR1(1524)

General description

C-X3-C motif chemokine receptor 1 (CX3CR1) is a transmembrane G-coupled chemokine receptor of its ligand, fractalkine. This receptor is expressed on epithelial cells, smooth muscle cells, microglia, monocytic cells and natural killer cells. The gene encoding CX3CR1 is localized on human chromosome 3p21.3 and has five exons.

Immunogen

Synthetic 19 amino acid peptide from 3rd extracellular domain of human CX3CR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (95%); Marmoset, Mouse, Panda (84%).

Biochem/physiol Actions

C-X3-C motif chemokine receptor 1 (CX3CR1) may be linked to the development of macular degeneration. It also acts as a receptor aiding viral entry.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-?B cascade in pancreatic cancer cells.
Wang H
Cell Biochemistry and Function, 35(6), 315-326 (2017)
CX3CR1 polymorphisms and the risk of age-related macular degeneration.
Ma B
International Journal of Clinical and Experimental Pathology, 8(8), 9592-9596 (2015)
CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.
Chirkova T
The Journal of General Virology, 96(9), 2543-2556 (2015)
Yuanyi Yue et al.
Frontiers in immunology, 12, 758040-758040 (2022-02-11)
The tumor microenvironment (TME) plays an important role in the pathogenesis of many cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) and identify possible prognostic biomarkers. The gene expression profiles and clinical data of 464
Chien-Ting Wu et al.
Cell, 186(1), 112-130 (2022-12-30)
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-CoV-2 traverses the mucus

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