SML0972

ORM-10103

≥98% (HPLC)

• Synonym(s): 2-[(3,4-Dihydro-2-phenyl-2H-1-benzopyran-6-yl)oxy]-5-nitro-pyridine
• Empirical Formula (Hill Notation): C₂₀H₁₆N₂O₄
• CAS Number: 488847-28-5
• Molecular Weight: 348.35
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• InChI: 1S/C20H16N2O4/c23-22(24)16-7-11-20(21-13-16)25-17-8-10-19-15(12-17)6-9-18(26-19)14-4-2-1-3-5-14/h1-5,7-8,10-13,18H,6,9H2
• InChI key: GZONLGPIHCCJOI-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ORM-10103 is a potent, specific inhibitor of the Na(+)/Ca(2+) exchanger, NCX. The compound ORM-10103 inhibits both inward and outward NCX currents with IC₅₀ values of 780 nM, and 960 nM, respectively. ORM-10103 blocks induced arrhythmias in canine cardiac tissue.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H413
• Precautionary Statements: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable