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69720

Sigma-Aldrich

1-Methylxanthine

≥97.0% (HPLC)

Synonym(s):

2,6-Dihydroxy-1-methylpurine

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About This Item

Empirical Formula (Hill Notation):
C6H6N4O2
CAS Number:
6136-37-4
Molecular Weight:
166.14
Beilstein:
171507
EC Number:
228-108-5
MDL number:
MFCD00005561
UNSPSC Code:
12352100
PubChem Substance ID:
57652204
NACRES:
NA.22

Assay

≥97.0% (HPLC)

form

powder

mp

≥300 °C

SMILES string

CN1C(=O)Nc2nc[nH]c2C1=O

InChI

1S/C6H6N4O2/c1-10-5(11)3-4(8-2-7-3)9-6(10)12/h2H,1H3,(H,7,8)(H,9,12)

InChI key

MVOYJPOZRLFTCP-UHFFFAOYSA-N

Gene Information

rat ... Adora1(29290) , Adora2a(25369)

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Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Seong-Yun Jeong et al.
International journal of pharmaceutics, 372(1-2), 132-139 (2009-01-27)
Most of methylxanthine derivatives including caffeine have been known to radiosensitize cancer cells, but the obstacles such as toxicity, request of high dose and poor solubility hinder their preclinical evaluations and clinical applications. In this study, we evaluated the efficacy
Catherine M Wheatley et al.
American journal of physiology. Endocrinology and metabolism, 287(4), E804-E809 (2004-06-24)
Exercise and insulin increase muscle glucose uptake by different mechanisms and also increase capillary recruitment, which is proposed to facilitate access for hormones and nutrients. The genetically obese Zucker rat shows impaired insulin- but not contraction-mediated glucose uptake in muscle.
Stephen Rattigan et al.
Exercise and sport sciences reviews, 33(1), 43-48 (2005-01-11)
Blood flow to contracting muscles is increased rapidly and is redistributed within the muscle. Recent research has highlighted that insulin causes similar changes, but these are absent in insulin resistance, resulting in impaired insulin-mediated muscle glucose uptake. Understanding the mechanisms
Hermann M Bolt et al.
Archives of toxicology, 79(4), 196-200 (2004-11-24)
A comparative study of N-acetyltransferase 2 (NAT2) genotyping and phenotyping (caffeine test method) was performed on 211 persons to elucidate apparent discrepancies in the assignment of NAT2*12 and NAT2*13 alleles which occur in the literature. The study used the standard
P St-Pierre et al.
Diabetes, obesity & metabolism, 14(8), 753-761 (2012-03-21)
Exercise and insulin each increase microvascular blood flow and enhance glucose disposal in skeletal muscle. We have reported that insulin-mediated microvascular recruitment in a diet-induced model of insulin resistance (high-fat feeding for 4 weeks) is markedly impaired; however, the effect
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