700131P
Avanti
24S,27-dihydroxycholesterol
Avanti Research™ - A Croda Brand 700131P, powder
Synonym(s):
(25S)-cholest-5-en-3β,24S,27-triol
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About This Item
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700131P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700131P
shipped in
dry ice
storage temp.
−20°C
General description
24S,27-dihydroxycholesterol differs from 24S-hydroxycholesterol in steroid nucleus by having an additional hydroxyl group. 24S,27-dihydroxycholesterol is derived from 24S-hydroxycholesterol in the presence of enzyme cholesterol 24-hydroxylase (P450 46A1).
Packaging
5 mL Amber Glass Screw Cap Vial (700131P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Biochemistry, 42(48), 14284-14292 (2003-12-03)
The known activity of cytochrome P450 46A1 (P450 46A1) is 24(S)-hydroxylation of cholesterol. This reaction produces biologically active oxysterol, 24(S)-hydroxycholesterol, and is also the first step in enzymatic degradation of cholesterol in the brain. We report here that P450 46A1
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