1.37124

Benzalkonium chloride solution

50% (aqueous solution), EMPROVE^® EXPERT, Ph. Eur., NF

• Synonym(s): Alkylbenzyldimethylammonium chloride
• CAS Number: 63449-41-2
• MDL number: MFCD00145757
• UNSPSC Code: 41116107

Properties

• biological source: synthetic
• Quality Level: 500
• Agency: NF; Ph. Eur.
• product line: EMPROVE^® EXPERT
• form: liquid
• packaging: pkg of 1 L
• concentration: 50% (aqueous solution); 50% in H₂O
• application(s): liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation
• storage temp.: 15-25°C
• InChI: 1S/C19H34N.ClH/c1-4-5-6-7-8-9-10-14-17-20(2,3)18-19-15-12-11-13-16-19;/h11-13,15-16H,4-10,14,17-18H2,1-3H3;1H/q+1;/p-1
• InChI key: TTZLKXKJIMOHHG-UHFFFAOYSA-M

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Benzalkonium chloride is typically used as preservative in liquid formulations, e.g. for topic, ophthalmic, nasal and parenteral applications. It is effective against a wide range of bacteria, yeast and fungi.
Due to a defined C12:C14 ratio with high batch-to-batch consistency, Benzalkonium chloride Emprove^® Expert provides higher solubility and antimicrobial activity. It can be used in combination with thimerosal, disodium edetate and benzyl alcohol to further increase antimicrobial activity.
This product is also available in pure form (Art.No. 137123).

Linkage

Emprove^® Documentation

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302,H314,H410
• Precautionary Statements: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2