8.52204

Fmoc-Glu(OBzl)-OH

Novabiochem^®

• Synonym(s): Fmoc-Glu(OBzl)-OH, N-α-Fmoc-L-glutamic acid γ-benzyl ester
• Empirical Formula (Hill Notation): C₂₇H₂₅NO₆
• CAS Number: 123639-61-2
• Molecular Weight: 459.49
• MDL number: MFCD00065642
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥96.0% (acidimetric); ≥97.0% (HPLC); ≥98% (TLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 70 °C (decomposition)
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 2-30°C
• SMILES string: N([C@@H](CCC(=O)OCc4ccccc4)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C27H25NO6/c29-25(33-16-18-8-2-1-3-9-18)15-14-24(26(30)31)28-27(32)34-17-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,23-24H,14-17H2,(H,28,32)(H,30,31)/t24-/m0/s1
• InChI key: HJJURMMMGPQIQP-DEOSSOPVSA-N

Description

General description

Building block for introduction of glutamic acid bearing TFA-labile benzyl ester side-chain protection. Benzyl group is removed by hydrogenation over Pd/C or with strong acids such as TFMSA. Prone to pyroglutamate formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Linkage

Replaces: 04-12-1019

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011C)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 96.0 %
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable