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O5380

Supelco

Oxethazaine

analytical standard

Synonym(s):

2-Hydroxyethyliminobis(N-[α,α-dimethylphenethyl]-N-methylacetamide), Oxetacaine

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About This Item

Empirical Formula (Hill Notation):
C28H41N3O3
CAS Number:
126-27-2
Molecular Weight:
467.64
EC Number:
204-780-5
MDL number:
MFCD00079202
UNSPSC Code:
41116107
PubChem Substance ID:
329818914
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2

InChI

1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

InChI key

FTLDJPRFCGDUFH-UHFFFAOYSA-N

General description

Oxethazaine is a topical anesthetic, administered as an antacid for treating pain associated with duodenal ulcer, esophagitis and gastritis.

Application

Oxethazaine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048F0668

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A Pap et al.
Acta medica Academiae Scientiarum Hungaricae, 37(3), 305-313 (1980-01-01)
The effect of submaximal doses of intravenous atropine and their combination with topical anaesthesia of the intestine by oxethazaine-HCl was investigated in conscious rats. I. Basal water, bicarbonate and protein secretion were significantly augmented after diversion of pancreatic juice. On
The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models
Lee Y-S, et al.
Pharmacology, Biochemistry, and Behavior, 105(3), 98-104 (2013)
Y Yamazaki
Digestive diseases and sciences, 27(9), 821-827 (1982-09-01)
The mechanism by which oxethazaine inhibits hydrochloric acid stimulation of pancreatic secretion and the endogenous release of secretin was studied in six dogs prepared with pancreatic and gastric fistulae. Oxethazaine reduced both pancreatic secretion and plasma secretin concentration evoked by
Claire Barber et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 15(4), 427-440 (2006-11-30)
GOAL OF THE WORK: Oral mucositis (OM) is a functionally destructive complication of aggressive head and neck cancer therapy, often resulting in intense pain, an inability to eat and drink and secondary malnutrition and dehydration. The barrier-forming properties of Gelclair
Y Masuda et al.
Biochemical pharmacology, 53(12), 1779-1787 (1997-06-15)
We previously reported that, in isolated perfused rat livers in a constant flow system, oxethazaine (OXZ) rapidly increased portal pressure (PP) accompanied by inhibition of oxygen uptake and the subsequent metabolic effects. In this study, hemodynamic changes were studied by
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