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P3300000

Progesterone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Pregnene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
57-83-0
Molecular Weight:
314.46
Beilstein:
1915950
MDL number:
MFCD00003658
UNSPSC Code:
41116107
PubChem Substance ID:
329820168
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

progesterone

manufacturer/tradename

EDQM

mp

128-132 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Gene Information

human ... PGR(5241)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Progesterone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Steroid hormone produced by the corpus luteum.
Sales restrictions may apply.

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Progesterone for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001667

Progesterone for impurity H identification, European Pharmacopoeia (EP) Reference Standard

BP449

Progesterone, British Pharmacopoeia (BP) Reference Standard

PHR2280

Progesterone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2563

11-Ketoprogesterone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8932

(20R)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8933

(17α)-Pregn-4-ene-3,20-dione, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8935

(20S)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8939

(20R)-3-Oxopregn-4-en-20-yl acetate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8943

(20S)-3-Oxopregn-4-en-20-yl acetate

PHR2905

Progesterone Related Compound H, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360FD,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Rudolf Kaaks et al.
International journal of cancer, 134(8), 1947-1957 (2013-10-25)
Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)
Siwen Yang et al.
American journal of obstetrics and gynecology, 211(1), 44-44 (2014-02-04)
The objective of this study was to determine the effect of probiotic Lactobacillus rhamnosus GR-1 supernatant (GR-1 SN) on lipopolysaccharide-induced preterm birth (PTB) and outputs of cytokines, chemokines, and progesterone in pregnant CD-1 mice. We compared PTB rates after intrauterine
Xiaofei Sun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(5), 2380-2389 (2014-01-29)
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is expressed in many organs, including female reproductive organs, and is a stem cell marker in the stomach and intestinal epithelium, hair follicles, and ovarian surface epithelium. Despite ongoing studies, the definitive physiological functions
Brett E Skolnick et al.
The New England journal of medicine, 371(26), 2467-2476 (2014-12-11)
Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase
Cathrin Brisken
Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)
Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase
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