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Key Documents

L7659

Sigma-Aldrich

Lewis-b tetrasaccharide

Synonym(s):

α-Fuc(1→2)-β-Gal-(1→3)-(α-Fuc-[1→4])-GlcNAc, Leb glycan

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About This Item

Empirical Formula (Hill Notation):
C26H45NO19
Molecular Weight:
675.63
MDL number:
MFCD01632618
UNSPSC Code:
12352200
PubChem Substance ID:
329817653
NACRES:
NA.32

storage temp.

−20°C

Quality Level

200

SMILES string

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@@H]3[C@@H](NC(C)=O)C(O)O[C@H](CO)[C@H]3O[C@@H]4O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]4O)[C@@H](O)[C@H](O)[C@@H]1O

InChI

1S/C26H45NO19/c1-6-12(31)15(34)18(37)24(40-6)44-20-10(5-29)42-23(39)11(27-8(3)30)21(20)45-26-22(17(36)14(33)9(4-28)43-26)46-25-19(38)16(35)13(32)7(2)41-25/h6-7,9-26,28-29,31-39H,4-5H2,1-3H3,(H,27,30)/t6-,7-,9+,10+,11+,12+,13+,14-,15+,16+,17-,18-,19-,20+,21+,22+,23?,24-,25-,26-/m0/s1

InChI key

OXNGKCPRVRBHPO-VIXGDSECSA-N

General description

The Lewis b (Leb) antigens are widely expressed in the proximal colon. During fetal development, Leb antigens are found throughout the colon, but after birth, they gradually diminish in the distal colon.

Application

Lewis-b tetrasaccharide has been used to treat the P protein for complex crystal growth.

Biochem/physiol Actions

The Lewis b (Leb) antigen reappearance is an excellent tumor marker for discriminating between malignant and benign tumors, and it can also be used in many cases of colon cancer.

Other Notes

Lewis-b human blood group determinant.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S Nishihara et al.
Glycobiology, 9(6), 607-616 (1999-05-25)
Lewis b (Leb) antigens are gradiently expressed from the proximal to the distal colon, i.e., they are abundantly expressed in the proximal colon, but only faintly in the distal colon. In the distal colon, they begin to increase at the
Ning Hao et al.
Protein & cell, 6(2), 101-116 (2014-12-31)
Human noroviruses (huNoVs) recognize histo-blood group antigens (HBGAs) as attachment factors, in which genogroup (G) I and GII huNoVs use distinct binding interfaces. The genetic and evolutionary relationships of GII huNoVs under selection by the host HBGAs have been well

Articles

Review of O-Linked Glycoproteins

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

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