15022AST
Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns
L × I.D. 10 cm × 4.6 mm, HPLC Column
Synonym(s):
CHIROBIOTIC V2 Chiral Chromatography Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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product name
Astec® CHIROBIOTIC® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L88
description
HPLC column
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
10 cm × 4.6 mm
matrix
High-purity silica gel particle platform
fully porous particle
matrix active group
vancomycin phase
particle size
5 μm
pore size
200 Å
operating pH range
3.5-7.0
separation technique
chiral
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General description
Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Vancomycin
- Operating pH range: 3.5 - 7.0
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
Application
- Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022).
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016).
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009).
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity
Fuglseth, Erik, et al.
Tetrahedron, 65 (47), 9807-9813 (2009)
Enantioenriched 1-aryl-2-fluoroethylamines. Efficient lipase-catalysed resolution and limitations to the Mitsunobu inversion protocol
Thvedt, Thor H?kon Krane, et al.
Tetrahedron, 66 (34), 6733-6743 (2010)
Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography?tandem mass spectrometry: Application to human ethanol interactions
Zhu, Hao-Jie, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (11-12), 783-788 (2011)
Direct and indirect separations of five isomers of Brivanib Alaninate using chiral high-performance liquid chromatography
He, Brian Lingfeng, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 875 (1), 122-135 (2008)
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