742600

Difluoromethyl phenyl sulfone

≥97%

• Synonym(s): PhSO₂CF₂H, [(Difluoromethyl)sulfonyl]benzene
• Empirical Formula (Hill Notation): C₇H₆F₂O₂S
• CAS Number: 1535-65-5
• Molecular Weight: 192.18
• Beilstein: 2259218
• MDL number: MFCD01050170
• UNSPSC Code: 12352101
• PubChem Substance ID: 329765583
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥97%
• form: solid
• functional group: fluoro; sulfone
• SMILES string: FC(F)S(=O)(=O)c1ccccc1
• InChI: 1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
• InChI key: LRHDNAVPELLXDL-UHFFFAOYSA-N

Description

Application

Reagent Used for

• Reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes
• Fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors
• Difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation

Reagent used in Preparation of

• α-difluoromethyl amines via stereoselective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines
• Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes
• β-difluoromethylated and β-difluoromethylenated alcohols and amines by regioselective nucleophilic difluoromethylation of 1,2-cyclic sulfates and sulfamidates
• Difluoroalkenes from alkyl halides via nucleophilic substitution-elimination
• Difluoromethyl alcohol derivatives from enolizable and non-enolizable carbonyl compounds using nucleophilic phenylsulfonyldifluoromethylation-reductive desulfonylation strategy
• Fluoromethylated vicinal ethylenediamines via fluoromethylation of chiral α-aminobutanesulfinimines with (phenylsulfonyl)fluoromethanes followed by reductive desulfonylation and alcoholysis

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 264.0 °F
• Flash Point(C): 128.9 °C