E-081
Etizolam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C17H15ClN4S
CAS Number:
Molecular Weight:
342.85
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland)
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
CCC1=CC2=C(S1)N3C(CN=C2C4=CC=CC=C4Cl)=NN=C3C
InChI
1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3
InChI key
VMZUTJCNQWMAGF-UHFFFAOYSA-N
General description
A certified solution standard for use in LC/MS or GC/MS benzodiazepine testing methods in clinical toxicology, urine drug testing, or forensic analysis. Etizolam, sold under brand names such as Etilaam, Etizola, or Depas, is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety, or panic attacks. Etizolam is also sold on the designer drug market with cases of abuse noted in Europe and the US.
Application
- A strategy for the detection of benzodiazepine drugs using low-resolution paper-spray mass spectrometry for harm reduction drug checking: This study explores the application of Etizolam in the development of low-cost, rapid mass spectrometric techniques for detecting benzodiazepines at harm reduction sites, emphasizing its utility in public health interventions (Miskulin et al., 2023).
- Unexpected results found in larvae samples from two postmortem forensic cases: Incorporates Etizolam to elucidate drug metabolism in forensic toxicology, highlighting its relevance in the postmortem analysis and its impact on forensic investigations (Groth et al., 2022).
- Rapid and accurate etizolam detection using surface-enhanced Raman spectroscopy for community drug checking: Demonstrates the use of Etizolam as a standard in developing cutting-edge, reliable spectroscopic methods for quick drug testing in community settings, thus advancing forensic and clinical toxicology (Gozdzialski et al., 2022).
- Incorporation of five common hypnotics into hair after a single dose and application to a forensic case of drug facilitated crimes: This research utilizes Etizolam in studies focused on drug deposition in hair, providing crucial insights for the forensic analysis of drug-facilitated crimes (Sasaki et al., 2021).
Biochem/physiol Actions
Etizolam is a thienodiazepine anxiolytic and as compared to other benzodiazepines has lower dependence potential. It differs from other benzodiazepines in that its molecules possess a thiophene ring instead of benzene. It has anticonvulsant, sedative, anxiolytic, amnesic, hypnotic and muscle relaxant properties. It′s mode of action is through benzodiazepine receptor. It is used to treat insomnia, moderate depression and social anxiety disorder, and has occasionally been associated with blepharospasm and skin lesions.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F
Flash Point(C)
9.7 °C
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Maria Pia De Candia et al.
Clinical therapeutics, 31(12), 2851-2859 (2010-01-30)
Etizolam is an anxiolytic drug with a pharmacologic profile similar to that of the classic benzodiazepines. Neurochemical research suggests that etizolam may have selectivity for the subpopulation of Y-aminobutyric acid type A receptors associated with anxiety (ie, alpha1, beta2, gamma2).
Takeshi Terao et al.
Progress in neuro-psychopharmacology & biological psychiatry, 31(1), 295-296 (2006-08-19)
A 65-year-old female patient with major depressive disorder suffered from clonus, shivering and impaired visual acuity after 20 mg/day of paroxetine administration. The symptoms were initially regarded as further manifestations of her somatic symptoms of depression, and paroxetine was increased
Akira Watanabe et al.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 39(5), 482-487 (2004-12-03)
Drug dependence is a social problem of over the world and resistant to medical intervention by psychiatrist as well as general clinicians. In Japan, methamphetamine dependence is one of the most critical social problems, but opioid dependence is relatively rare.
Akira Namera et al.
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 24(1), 27-34 (2011-04-13)
The immunoassay screening of benzodiazepines in urine is one of the most important methods of drug analysis in clinical and forensic laboratories. We experienced an unusual case of poisoning wherein the result of Triage DOA immunoassay screening was negative, although
Masahiro Hirase et al.
European journal of pharmacology, 597(1-3), 46-50 (2008-09-16)
The present study was performed to examine whether or not rebound insomnia is caused by an abrupt withdrawal of benzodiazepine hypnotics and tandospirone in rats. Etizolam and triazolam caused a significant shortening of sleep latency, increase in non-REM sleep time
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