1.00013

Acetone

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JPE, NF

• Synonym(s): Dimethyl ketone, Propanone, 2-Propanone
• Linear Formula: CH₃COCH₃
• CAS Number: 67-64-1
• Molecular Weight: 58.08
• Beilstein: 635680
• MDL number: MFCD00008765
• UNSPSC Code: 12352115
• EC Index Number: 200-662-2

Properties

• Agency: BP; JPE; NF; Ph. Eur.
• Quality Level: 500
• vapor density: 2 (vs air)
• vapor pressure: 184 mmHg ( 20 °C)
• description: EMPROVE^® ESSENTIAL Ph Eur,BP,JPE,NF
• product line: EMPROVE^® ESSENTIAL
• Assay: ≥99% (GC)
• form: liquid
• autoignition temp.: 465 °C (DIN 51794)
• expl. lim.: 13.2 %
• technique(s): API processing | polymorph screening: suitable
• refractive index: n20/D 1.359 (lit.)
• pH: 5-6 (20 °C, 395 g/L in H₂O)
• capacity: 1000 g/kg water absorbing capacity
• bp: 56 °C/760 mmHg (lit.)
• mp: −94 °C (lit.)
• transition temp: flash point <-20 °C
• density: 0.791 g/mL at 25 °C (lit.)
• application(s): liquid formulation; pharma/biopharma processes; pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: CC(C)=O
• InChI: 1S/C3H6O/c1-3(2)4/h1-2H3
• InChI key: CSCPPACGZOOCGX-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Acetone is used as solvent in a variety of pharmaceutical production processes, e. g. tablet coating, granulation, and microsphere production. It is also applied as solvent or co-solvent in topical formulations.

Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319,H336
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 1.4 °F - closed cup
• Flash Point(C): -17.0 °C - closed cup