1.13126

Silicon dioxide

colloidal, highly dispersed, EMPROVE^® ESSENTIAL, Ph. Eur., JP, NF, E 551

• Synonym(s): Silica, Silicon dioxide
• Linear Formula: SiO₂
• CAS Number: 7631-86-9
• Molecular Weight: 60.08
• MDL number: MFCD00011232
• UNSPSC Code: 12352309
• E Number: E551
• EC Index Number: 231-545-4

Properties

• Agency: JP; NF; Ph. Eur.
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: solid
• pH: 7 (20 °C, 100 g/L in H₂O, slurry)
• bp: 2230 °C (lit.)
• mp: >1600 °C (lit.)
• application(s): liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 15-25°C
• SMILES string: O=[Si]=O
• InChI: 1S/O2Si/c1-3-2
• InChI key: VYPSYNLAJGMNEJ-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Silicon dioxide is a widely used ingredient in food and pharmaceutical applications. Its application includes the use as a viscosity-increasing agent and emulsion stabilizer in liquid formulations as well as the use as flow regulator or glidant to improve flow properties of dry powders in tablet and capsule manufacturing.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H372
• Precautionary Statements: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1 Inhalation
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable