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Key Documents

6.18723

Sigma-Aldrich

NMP

for chromatography

Synonym(s):

1-Methyl-2-pyrrolidone

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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
872-50-4
Molecular Weight:
99.13
MDL number:
MFCD00003193
UNSPSC Code:
12352005

Product Name

1-Methyl-2-pyrrolidone, for chromatography

grade

for chromatography

Quality Level

100

SMILES string

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

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General description

1-Methyl-2-pyrrolidone is a dipolar aprotic solvent widely used in organic chemistry for its ability to dissolve many chemicals. It is commonly used as a solvent or eluent for extracting soluble materials from soil samples using size-exclusion chromatography. NMP is a highly polar liquid and can be used for solvent extraction of polar substances from non-polar substances.

Application


  • Delivery of atovaquone and proguanil across sublingual membranes, in vitro.: This study explores the sublingual delivery of the antimalarial drugs atovaquone and proguanil, using 1-Methyl-2-pyrrolidone (NMP) as a solubilizing agent to enhance drug permeability. Results demonstrate NMP′s potential to improve drug delivery efficiency through sublingual membranes (Wallace et al., 2012).

  • Controlled delivery of aspirin: effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems.: This research investigates the controlled release of aspirin from poly(lactic-co-glycolic acid) (PLGA) systems using NMP. The study highlights NMP′s role in modulating polymer degradation and drug release profiles, offering insights for developing controlled delivery systems (Tang and Singh, 2008).


Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H335,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

195.8 °F - Pensky-Martens closed cup

Flash Point(C)

91 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

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1-methyl-2-pyrrolidone: from exfoliating solvent to a paramagnetic ligand
Lemus-Santana AA, et al.
The Journal of Physical Chemistry A, 117(11), 2400-2407 (2013)
Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat
Morgan TJ, et al.
Journal of Chromatography A, 1095(1-2), 81-88 (2005)
Densities, viscosities, sound speed, and IR studies of N-methyl-2-pyrrolidone with cyclohexylamine, cyclohexanol, and cyclohexene at different temperatures
Reddy KR, et al.
Thermochimica Acta, 590, 116-126 (2014)

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