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D5879

Sigma-Aldrich

Dimethyl sulfoxide

ReagentPlus®, ≥99.5%

Synonym(s):

DMSO

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About This Item

Linear Formula:
(CH3)2SO
CAS Number:
67-68-5
Molecular Weight:
78.13
Beilstein:
506008
EC Number:
200-664-3
MDL number:
MFCD00002089
UNSPSC Code:
12191502
PubChem Substance ID:
329798814
NACRES:
NA.21
grade:
reagent
technique(s):
immunoblotting: suitable
bp:
189 °C (lit.)
vapor pressure:
0.42 mmHg ( 20 °C)
Pricing and availability is not currently available.

grade

reagent

Quality Level

200

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

product line

ReagentPlus®

Assay

≥99.5%

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

immunoblotting: suitable

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General description

Dimethyl sulfoxide is an amphipathic molecule, soluble in both aqueous and organic solvents.[1] It is commonly used as an aprotic solvent[2] and also as a reagent in organic synthesis.[3]

Application

DMSO has been used as a medium to prepare a chemiluminescence reagent that can be a substitute to commercially-available enhanced chemiluminescence kits for use in immunoblotting technique.[4]

Biochem/physiol Actions

DMSO is a highly polar substance that can be used as an industrial solvent for organic and inorganic chemicals. It is also used as a protectant during cold storage of living cells.[5][6] It is also useful for the oxidation of thiols and disulfides to sulfonic acids.[7]

Packaging

Note: D5879-1L in glass bottle /D5879-1L-D in poly bottle.

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Other Notes

For information on dimethyl sulfoxide miscibility, please visit the following link:
Dimethyl Sulfoxide Miscibility/Immiscibility Table

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS5696
SHBS4012
SHBR5702
SHBR8760
SHBR7065

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Levent Keskintepe et al.
Journal of assisted reproduction and genetics, 26(11-12), 629-635 (2009-12-08)
Cryopreservation of blastocysts, especially those subjected to the trauma due to blastomere biopsy for the purposes of pre-implantation genetic screening (PGS), requires significant optimization. Laboratory and clinical outcomes were compared to determine the effect of two different cryopreservation techniques on
Julia L Zehr et al.
Biology of reproduction, 72(5), 1087-1094 (2004-12-31)
This study investigated whether prenatal androgen exposure, social rank, and body weight are factors regulating pubertal development in outdoor-housed female rhesus monkeys. Subjects' mothers received injections of testosterone enanthate (20 mg/ wk), flutamide (an androgen receptor blocker, 30 mg/kg twice
Lowe, O.G
The Journal of Organic Chemistry, 41 (1976)
Sun-A Ock et al.
Cell transplantation, 20(8), 1231-1239 (2011-02-08)
Dimethyl sulfoxide (DMSO), a commonly used cryoprotectant in cryopreservation procedures, is detrimental to viability of cells. In this view point, a comparative study was carried out to evaluate the effect of DMSO on porcine mesenchymal stem cells (pMSCs). We compared
M Bouquet et al.
Molecular reproduction and development, 40(1), 110-115 (1995-01-01)
In a previous study, we have shown that the cryopreservation of mouse oocytes caused increases in the rates of degeneration and of digynic polyploid embryos, while the fertility of frozen-thawed oocytes was decreased. In this study, we have attempted to
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