C9750

β-Carotene

synthetic, ≥93% (UV), powder

• Synonym(s): β,β-Carotene, Provitamin A
• Empirical Formula (Hill Notation): C₄₀H₅₆
• CAS Number: 7235-40-7
• Molecular Weight: 536.87
• Beilstein: 1917416
• EC Number: 230-636-6
• MDL number: MFCD00001556
• UNSPSC Code: 12352205
• PubChem Substance ID: 24893189
• NACRES: NA.79

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥93% (UV)
• form: powder
• potency: ~1,600,000 units vitamin A per g
• color: dark red to brown
• mp: 178-179 °C
• solubility: hexane: 1.1 mg/mL; DMSO: 30 μg/mL
• storage temp.: −20°C
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1
• InChI: 1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+
• InChI key: OENHQHLEOONYIE-JLTXGRSLSA-N

Description

General description

Carotenoids are an important class of naturally occurring pigments found in fruits and vegetables. Among the carotenoids, β-carotene has the greatest provitamin A potential and functions to reduce the risk of cancer, cardiovascular diseases and macular degeneration. Low water solubility and poor chemical stability attributes to low absorption of β-carotene from food. β-carotene along with digestible lipids enriches its bio accessibility. Emulsions or nano emulsions encapsulates effectively delivers lipophilic β-carotene and increases its bioavailability. β-carotene has anti-oxidant potential and reduces noise induced hearing loss and progression of macular degeneration.

Application

β-carotene has been used:

• to generate nano emulsions to evaluate their bioavailability potential
• as a standard, for β-carotene evaluation in blood and skin samples using high performance liquid chromatography (HPLC),
• as a dietary supplement of vitamin-A in young rats by HPLC
• as a dietary supplement in mice to reduce hearing loss and hair cell damage

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

Packaging

Packaged in serum vials.

Caution

Purchase minimum quantity required. Discard one month after opening.

Safety Information

• WGK: WGK 1
• Flash Point(F): 217.9 °F - closed cup
• Flash Point(C): 103.3 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves