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R9525

Sigma-Aldrich

RX 821002 hydrochloride

solid, ≥98% (HPLC)

Synonym(s):

2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O3 · HCl
CAS Number:
109544-45-8
Molecular Weight:
270.71
MDL number:
MFCD00069343
UNSPSC Code:
12352200
PubChem Substance ID:
24278684
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

SMILES string

Cl[H].COC1(COc2ccccc2O1)C3=NCCN3

InChI

1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H

InChI key

IMPOOMVZVWKSAP-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor antagonist

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000395015
0000395015
027M4717V
010M4616V

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M M Rank et al.
Journal of neurophysiology, 105(1), 410-422 (2010-11-05)
The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated
Yia-Ping Liu et al.
Journal of biomedical science, 16, 72-72 (2009-08-15)
The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0 and 10 mg/kg) in the
Axel Rominger et al.
Synapse (New York, N.Y.), 64(8), 654-657 (2010-03-26)
To test for alpha(2) adrenergic modulation of dopamine D(2/3) receptor availability in striatum of living mice using the high-affinity ligand [(18)F]fallypride and microPET. Groups of anesthetized mice were pretreated with saline, the alpha(2)-agonist clonidine (1 mg/kg), and the alpha(2)-antagonists RX821002
S Gasparini et al.
Neuroscience, 164(2), 370-379 (2009-09-01)
The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present
A Bai et al.
Clinical and experimental immunology, 156(2), 353-362 (2009-03-03)
Inflammatory bowel disease (IBD) is characterized by heavy production of proinflammatory cytokines such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta. Interactions of the autonomic nervous system with local immune cells play an important role in the development of IBD
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