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Key Documents

SAB5700817

Sigma-Aldrich

Anti-p53 antibody produced in rabbit

Synonym(s):

BCC7, LFS1, P53, TP53, TRP53, Tp53, Trp53, bbl, bfy, bhy, p44, p53

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

43

species reactivity

human, rat, mouse

concentration

1.14 mg/ml

technique(s)

ChIP: 1:20-1:50
immunohistochemistry: 1:50-1:200
immunoprecipitation (IP): 1:20-1:50
western blot: 1:3000-1:6000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TP53(7157)
mouse ... Trp53(22059)

General description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 (NP_000537.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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