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SML2390

Sigma-Aldrich

JNS 1-40

≥95% (HPLC)

Synonym(s):

N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C17H16ClNO3
CAS Number:
2241773-03-3
Molecular Weight:
317.77
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CCl)N(CC1=CC=CC=C1)C2=CC3=C(OCCO3)C=C2

InChI

1S/C17H16ClNO3/c18-11-17(20)19(12-13-4-2-1-3-5-13)14-6-7-15-16(10-14)22-9-8-21-15/h1-7,10H,8-9,11-12H2

InChI key

POYZNHCCXQEULA-UHFFFAOYSA-N

Biochem/physiol Actions

JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Elizabeth A Grossman et al.
Cell chemical biology, 24(11), 1368-1376 (2017-09-19)
Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites

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