T0910
Thioredoxin from Escherichia coli
recombinant, expressed in E. coli, essentially salt-free, lyophilized powder, ≥3 units/mg protein
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About This Item
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biological source
Escherichia coli
Quality Level
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
essentially salt-free, lyophilized powder
specific activity
≥3 units/mg protein
mol wt
11.7 kDa
technique(s)
activity assay: suitable
solubility
water: 1.90-2.10 mg/mL, clear, colorless
Protein ID accession no.
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Gene Information
Escherichia coli K12 ... trxA(948289)
General description
Research area: Cell Signaling
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.
Application
Thioredoxin from Escherichia coli has been used in thioredoxin reductase assay, peroxidase-coupled thioredoxin system assay and peroxiredoxin assay. It has also been used to study its effects on photoreceptor death in a mouse model of retinitis pigmentosa (RP) and its potential to modify retinal oxidative stress, glial changes, and vascular changes during the progression of the disease.
Biochem/physiol Actions
Thioredoxin from Escherichia coli catalyzes REDOX reactions and has a role in various biological processes. It modulates the structure and activity of many proteins. The enzyme thioredoxin reductase catalyzes the reduction of thioredoxin. Thioredoxin also has a role in oxidative stress response.Thioredoxin, known as both adult T cell leukemia-derived factor (ADF) and a cellular redox enzyme, functions as a cytokine or chemokine, facilitating cell-to-cell communication. Additionally, it plays a role in regulating cell growth and apoptosis.
Mediates the reduction of disulfide bonds in proteins.
Other Notes
GenBank® Accession Number M26133.
Unit Definition
One unit will cause a ΔA650 of 1.0 in 1 min at 25 °C in the insulin reduction assay.
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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