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T3396

Sigma-Aldrich

Tetraglycol

BioXtra

Synonym(s):

Glycofurol, Tetrahydrofurfuryl alcohol polyethyleneglycol ether

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About This Item

CAS Number:
31692-85-0
MDL number:
MFCD00801146
UNSPSC Code:
12352201
NACRES:
NA.25

description

non-ionic

Quality Level

200

product line

BioXtra

form

liquid (clear)

impurities

<0.5% water (Coulometric)
<5 ppm heavy metal

color

colorless to light yellow

mp

≤ -100  °C

solubility

water: soluble 3420 g/L

density

1.09 g/mL at 25 °C (lit.)

InChI

1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2

InChI key

CTPDSKVQLSDPLC-UHFFFAOYSA-N

Related Categories

Application

Tetraglycol has been used:
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) for injecting fertilized chicken eggs for DiI labeling
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) and diO (3,3′-dioctadecyloxacarbocyanine perchlorate) for dye/virus injections
  • to dilute poly (lactide-co-glycolide) (PLGA) to prepare PLGA/F127 solution

Used as solvent to dissolve water-insoluble compounds.

Biochem/physiol Actions

Liquid glycofurol can readily transform into gel systems with excellent elasticity due to which, it can be used as a medium to dissolve water-insoluble drugs.

Features and Benefits

Efficient solubilizer for glibenclamide (GBD)

Caution

Do not confuse with tetraethylene glycol, which is also sometimes called tetraglycol.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

275.0 °F - closed cup

Flash Point(C)

135 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nahla Salah Barakat
AAPS PharmSciTech, 11(3), 1138-1146 (2010-07-24)
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property
X F Zhang et al.
Materials science & engineering. C, Materials for biological applications, 32(6), 1654-1663 (2012-08-01)
Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the
Saly Galal et al.
Acta pharmaceutica (Zagreb, Croatia), 53(1), 57-64 (2004-02-11)
The ability of liquid and semi-solid matrix (SSM) filling capsule technology to improve the dissolution rate of glibenclamide (GBD) was investigated. Semiquantitative estimation of GBD solubility in various vehicles was carried out. Tetraglycol was found to be the most efficient
S Kehoe et al.
Journal of the mechanical behavior of biomedical materials, 14, 180-185 (2012-10-03)
PLGA/pluronic F127 based nerve guidance conduits (NGCs) for peripheral nerve regeneration offer excellent potential for clinical use. To date, little emphasis has been directed towards the effect of pluronic F127 on their subsequent mechanical properties as a function of degradation

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