T6700
TRAM-34
≥98% (HPLC), solid
Synonym(s):
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
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About This Item
Empirical Formula (Hill Notation):
C22H17ClN2
CAS Number:
Molecular Weight:
344.84
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: 2 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI key
KBFUQFVFYYBHBT-UHFFFAOYSA-N
Application
TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.
Biochem/physiol Actions
TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
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The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to
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