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V900421

Sigma-Aldrich

Uridine

Vetec™, reagent grade, 99%

Synonym(s):

1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
58-96-8
Molecular Weight:
244.20
Beilstein:
754902
MDL number:
MFCD00006526
UNSPSC Code:
12352204
PubChem Substance ID:
329829829

grade

reagent grade

product line

Vetec™

Assay

99%

form

powder

mp

163-167 °C (lit.)

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

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General description

Uridine is a pyrimidine nucleoside composed of uracil and ribose that is readily taken up by the brain. This compound is synthesized de novo in mammals. It is found circulating in the blood and cerebrospinal fluid.

Biochem/physiol Actions

Uridine is an essential compound involved in maintaining cellular function and energy metabolism. It aids in multiple biological processes, including RNA synthesis, the synthesis of biomembranes, and glycosylation. Furthermore, uridine serves as a precursor molecule for UDP-glucose, a vital component in the synthesis and storage of glycogen in the liver. In addition, studies have shown that uridine reduces cytotoxicity and improves neurophysiological functions. It is involved in regulating various normal physiological processes in the body, including the cardio-circulatory, reproductive, peripheral and central nervous, and respiratory systems.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
Laure Jobert et al.
Molecular cell, 49(2), 339-345 (2012-12-19)
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that removes uracil and oxidised pyrimidines from DNA. We show that SMUG1 interacts with the pseudouridine synthase Dyskerin (DKC1) and colocalizes with DKC1 in nucleoli and Cajal bodies.
Yuan Zhou et al.
Nucleic acids research, 41(13), 6664-6673 (2013-05-10)
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs)
Juma A M Ali et al.
Molecular pharmacology, 83(2), 439-453 (2012-11-29)
African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis
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