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146188

Sigma-Aldrich

2-Hydroxy-5-methoxybenzoic acid

98%

Synonym(s):

5-Methoxysalicylic acid

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About This Item

Linear Formula:
CH3OC6H3(OH)CO2H
CAS Number:
Molecular Weight:
168.15
Beilstein:
2209647
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

powder

mp

141-143 °C (lit.)

functional group

carboxylic acid

SMILES string

COc1ccc(O)c(c1)C(O)=O

InChI

1S/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11)

InChI key

IZZIWIAOVZOBLF-UHFFFAOYSA-N

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General description

2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).

Application

2-Hydroxy-5-methoxybenzoic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Stephanie Holst et al.
Scientific reports, 7(1), 16623-16623 (2017-12-02)
To characterise pancreatic cancer cells from different sources which are used as model systems to study the metastatic behaviour in pancreatic ductal adenocarcinoma (PDAC), we compared the N-glycan imprint of four PDAC cells which were previously shown to differ in
Kathrin Stavenhagen et al.
Molecular & cellular proteomics : MCP, 17(6), 1225-1238 (2017-12-14)
Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of the contact activation pathway as well as the classical and lectin complement pathways. It is known to be a highly glycosylated plasma glycoprotein. However, both the structural
Lise Hafkenscheid et al.
Molecular & cellular proteomics : MCP, 16(2), 278-287 (2016-12-14)
Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). As N-linked glycans can mediate a variety of biological functions, we now aimed at investigating the structural composition of the Fab-glycans of
Beatriz Gonçalves et al.
Journal of experimental botany, 68(21-22), 5801-5811 (2017-12-01)
The CUP-SHAPED COTYLEDON (CUC) transcription factors control plant boundary formation, thus allowing the emergence of novel growth axes. While the developmental roles of the CUC genes in different organs and across species are well characterized, upstream and downstream events that
Cole Emanuelson et al.
SLAS discovery : advancing life sciences R & D, 26(1), 58-66 (2020-09-30)
High-throughput matrix-assisted laser desorption/ionization mass spectrometry (HT-MALDI-MS) has garnered considerable attention within the drug discovery industry as an information-rich alternative to assays using light-based detection methods. To date, these efforts have been primarily focused on assays using protein or peptide

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