Behavioral and corticotropic effects of ACTH during early postnatal ontogeny in rats.

Behavioral and corticotropic effects of ACTH during early postnatal ontogeny in rats.

Bulletin of experimental biology and medicine (2013-03-15)

T V Shemenkova, T S Kalinina, G T Shishkina, N N Dygalo

ABSTRACT

ACTH1-24(1 mg/kg) administered to 5-7-day-old rats reduced their locomotor activity and did not alter blood levels of corticosterone. ACTH administration on postnatal days 12-14 increased corticosterone levels, but had no effect on locomotor activity. Thus, the behavioral effect of ACTH is not due to corticotropic action of the hormone and is not associated with blood levels of glucocorticoids.

MATERIALS

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Brand

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46148

Supelco

Corticosterone, VETRANAL^®, analytical standard

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C2505

Sigma-Aldrich

Corticosterone, ≥92%

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Quantity

27840

Sigma-Aldrich

Corticosterone, ≥98.5% (HPLC)

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C-117

Supelco

Corticosterone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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