140732

N,N-Dimethylformamide dimethyl acetal

technical grade, 94%

• Synonym(s): 1,1-Dimethoxy-N,N-dimethylmethylamine, 1,1-Dimethoxytrimethylamine
• Linear Formula: (CH₃)₂NCH(OCH₃)₂
• CAS Number: 4637-24-5
• Molecular Weight: 119.16
• Beilstein: 506020
• EC Number: 225-063-3
• MDL number: MFCD00008482
• UNSPSC Code: 12352302
• PubChem Substance ID: 24848474
• NACRES: NA.22

Properties

• grade: technical grade
• Quality Level: 200
• Assay: 94%
• form: liquid
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.396 (lit.)
• bp: 102-103 °C/720 mmHg (lit.)
• density: 0.897 g/mL at 25 °C (lit.)
• functional group: amine; ether
• SMILES string: COC(OC)N(C)C
• InChI: 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
• InChI key: ZSXGLVDWWRXATF-UHFFFAOYSA-N

Description

Application

N,N-Dimethylformamide dimethyl acetal (DMF-DMA) can be used as: 

• An organocatalyst for the synthesis of 1,2-disubstituted-3,4-dihydronaphthalenes by the reaction of vinylarenes and electron-deficient alkynes.       
• A building block for the preparation of heterocyclic compounds such as enamines and amidines via formylation of methylene and amino groups.       
• A reagent in the synthesis of 1,4-diaryl-piperazine-2,5-diones by reacting with chloroacetamides.        
• A reagent along with enamine and alkyne for the preparation of 2,3,4,5-tetrasubstituted pyridine derivatives by three-component coupling reaction in the presence of Me₃SiCl.

Safety Information

• Pictograms: GHS02,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H317,H318,H332
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Skin Sens. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 42.8 °F
• Flash Point(C): 6 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves