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154377

Sigma-Aldrich

2-Benzofuranyl methyl ketone

99%

Synonym(s):

2-Acetylbenzofuran

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About This Item

Empirical Formula (Hill Notation):
C10H8O2
CAS Number:
1646-26-0
Molecular Weight:
160.17
EC Number:
216-706-9
MDL number:
MFCD00005849
UNSPSC Code:
12352100
PubChem Substance ID:
24849434
NACRES:
NA.22

Quality Level

200

Assay

99%

form

solid

bp

110-113 °C/3 mmHg (lit.)

mp

70-72 °C (lit.)

functional group

ketone

SMILES string

CC(=O)c1cc2ccccc2o1

InChI

1S/C10H8O2/c1-7(11)10-6-8-4-2-3-5-9(8)12-10/h2-6H,1H3

InChI key

YUTFQTAITWWGFH-UHFFFAOYSA-N

General description

Microwave assisted Claisen-Schmidt condensation of 2-acetylbenzofuran was studied.

Application

2-Benzofuranyl methyl ketone ( 2-Acetylbenzofuran) has been used to synthesize many benzofuran derivatives. It is also used to prepare fluorinated chalcones.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

154377-VAR:
154377-100G:
154377-25G:
154377-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000194522
0000184562
MKCK6535
MKCF0230
MKBW7175V

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Methyl ethyl ketone United States Pharmacopeia (USP) Reference Standard

USP

1430101

Methyl ethyl ketone

2-Furyl methyl ketone 99%

Sigma-Aldrich

A16254

2-Furyl methyl ketone

Tejpal Singh Chundawat et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 10(4), 409-417 (2013-08-06)
A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted Claisen-Schmidt condensation of 2-acetylbenzofuran (3) with fluorinated benzaldehydes (4) afforded corresponding fluorinated chalcones (5a-g).
Samia M Rida et al.
Archives of pharmacal research, 29(10), 826-833 (2006-11-24)
Previously, we synthesized and evaluated several benzofuran derivatives containing heterocyclic ring substituents linked to the benzofuran nucleus at C-2 by a two- to four-atom spacer as potential anti-HIV-1, anticancer and antimicrobial agents. Among these derivatives, NSC 725612 and NSC 725716

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