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Safety Information

230235

Sigma-Aldrich

Diphenylphosphinic chloride

98%

Synonym(s):

Diphenylchlorophosphine oxide, Diphenylphosphinic acid chloride, Diphenylphosphinoyl chloride, Diphenylphosphinyl chloride, Diphenylphosphorus oxychloride, Ph2POCl, Chlorodiphenylphosphine oxide

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About This Item

Linear Formula:
(C6H5)2P(O)Cl
CAS Number:
1499-21-4
Molecular Weight:
236.63
Beilstein:
975191
EC Number:
216-107-2
MDL number:
MFCD00002077
UNSPSC Code:
12352002
PubChem Substance ID:
24853787
NACRES:
NA.22

Quality Level

100

Assay

98%

form

liquid

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

refractive index

n20/D 1.609 (lit.)

bp

222 °C/16 mmHg (lit.)

density

1.24 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

ClP(=O)(c1ccccc1)c2ccccc2

InChI

1S/C12H10ClOP/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

InChI key

QPQGTZMAQRXCJW-UHFFFAOYSA-N

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Application

Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.

Signal Word

Danger

Hazard Statements

H226,H314,H317

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

78.8 °F - closed cup

Flash Point(C)

26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

230235-50G:
230235-BULK:
230235-5G:
230235-5KG:
230235-10G:
230235-1KG:
230235-100G:
230235-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
STBL4192
SDBB0853
STBK9309
STBK3049
STBJ9694

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Meifang Wang
Inorganic Chemistry, 33, 6, 1184-1187 (1994)
Difluorphos, an Electron?Poor Diphosphane: A Good Match Between Electronic and Steric Features.
Jeulin S, et al.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 116(3), 324-329 (2004)
Atropisomeric amides as chiral ligands: Using (−)-sparteine-directed enantioselective silylation to control the conformation of a stereogenic axis.
Clayden J, et al.
The Journal of Organic Chemistry, 65(21), 7033-7040 (2000)
Indium?Mediated Asymmetric Allylation of Acylhydrazones Using a Chiral Urea Catalyst.
Tan K L and Jacobsen E N
Angewandte Chemie (International Edition in English), 46(8), 1315-1317 (2007)
Efficient syntheses of korupensamines A, B and michellamine B by asymmetric Suzuki-Miyaura coupling reactions.
Xu G, et al.
Journal of the American Chemical Society, 136(2), 570-573 (2013)
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