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Safety Information

284270

Sigma-Aldrich

Phosphonoacetic acid

98%

Synonym(s):

(Carboxymethyl)phosphonic acid, 2-Phosphonoacetic acid, Fosfonoacetic acid, Phosphonacetic acid

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About This Item

Linear Formula:
(HO)2P(O)CH2CO2H
CAS Number:
4408-78-0
Molecular Weight:
140.03
EC Number:
224-558-1
MDL number:
MFCD00004311
UNSPSC Code:
12352100
PubChem Substance ID:
24857145
NACRES:
NA.22

Quality Level

100

Assay

98%

form

powder or crystals

mp

143-146 °C (lit.)

solubility

water: soluble 100 mg/mL, clear to very slightly hazy, colorless

functional group

carboxylic acid

SMILES string

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

InChI key

XUYJLQHKOGNDPB-UHFFFAOYSA-N

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General description

Phosphonoacetic acid inhibits specifically human cytomegalovirus DNA synthesis in virus-infected human fibroblasts. It also inhibits the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro.

Application

Phosphonoacetic acid was used as an inhibitor of viral DNA replication, to investigate the infected cell protein 0 (bICP0) localization in infected low passage bovine cells. It was also used as a phosphorus source for microbial growth in phosphate-independent manner.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

284270-VAR:
284270-BULK:
284270-50G:
284270-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW3645
MKCT6904
MKCT0828
MKCQ8338
MKCP9483

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Lauren M Oko et al.
PLoS pathogens, 15(6), e1007849-e1007849 (2019-06-06)
Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter flow cytometry, to study the
Vincent Li et al.
Journal of molecular biology, 400(3), 295-308 (2010-05-25)
Structure-based protein sequence alignments of family B DNA polymerases revealed a conserved motif that is formed from interacting residues between loops from the N-terminal and palm domains and between the N-terminal loop and a conserved proline residue. The importance of
A Abendroth et al.
Journal of virology, 75(10), 4878-4888 (2001-04-20)
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T lymphocytes. By flow cytometry, VZV infection reduced the cell surface expression of
T Sairenji et al.
The Journal of general virology, 38(1), 111-120 (1978-01-01)
This study investigated the synthesis of membrane antigen (MA) as well as virus capsid antigen (VCA) and early antigen (EA) in Daudi cells which had been superinfected with the P3HR-1 strain of Epstein-Barr virus (EBV) and then treated with trypsin
Adam D Lietzan et al.
Biochemistry, 50(45), 9708-9723 (2011-10-01)
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the
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