320293

Dimethyl sulfate

≥99%

• Synonym(s): Sulfuric acid dimethyl ester
• Linear Formula: (CH₃O)₂SO₂
• CAS Number: 77-78-1
• Molecular Weight: 126.13
• Beilstein: 635994
• EC Number: 201-058-1
• MDL number: MFCD00008416
• UNSPSC Code: 12352108
• PubChem Substance ID: 24859257
• NACRES: NA.22
• Assay: ≥99%
• bp: 188 °C (lit.)
• vapor pressure: 0.7 mmHg ( 25 °C)

Properties

• vapor density: 4.3 (vs air)
• Quality Level: 200
• vapor pressure: 0.7 mmHg ( 25 °C)
• Assay: ≥99%
• form: liquid
• autoignition temp.: 923 °F
• refractive index: n20/D 1.386 (lit.)
• bp: 188 °C (lit.)
• mp: −32 °C (lit.)
• density: 1.333 g/mL at 25 °C (lit.)
• SMILES string: COS(=O)(=O)OC
• InChI: 1S/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3
• InChI key: VAYGXNSJCAHWJZ-UHFFFAOYSA-N

Description

Application

Dimethyl sulfate is a powerful methylating reagent for the methylation of carboxylic acids, alcohols, phenols, lactams, oximes, hydroxylamines, and hydroperoxides. It can be used as a reagent for the preparation of N-methyl alkyl- and aryl-substituted amines, amides, and quaternary ammonium salts. Dimethyl sulfate is also used in the methylation of sulfur-containing compounds to synthesize sulfides and sulfonium ions.
It can also be used as a reagent:       

• For the preparation of quaternary ammonium acrylic monomer as a potent antibacterial agent by the quaternization of 2-dimethylamino ethyl methacrylate.       
• Along with dimethyl sulfoxide for the synthesis of epoxides from aldehydes and ketones via formation of trimethylsulfonium cation.      
• To prepare an oxygenate additive for diesel by the methylation of glycerol.

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H314,H317,H330,H341,H350
• Precautionary Statements: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 181.4 °F - closed cup
• Flash Point(C): 83 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves