Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

379891

Sigma-Aldrich

Periodic acid

99.999% trace metals basis

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
12352301
PubChem Substance ID:
24863698
NACRES:
NA.22

Quality Level

200

Assay

99.999% trace metals basis

form

crystals

reaction suitability

reagent type: oxidant

mp

122 °C (lit.)

solubility

water: soluble

SMILES string

OI(O)(O)(O)(O)=O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Periodic acid (H5IO6) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions.

Application

Periodic acid can be used as a reagent:
  • In the oxidative cleavage of 1,2 diols and epoxides to ketones or aldehydes.
  • For the oxidation of alcohols to ketones or aldehydes in the presence of pyridinium chlorochromate as a catalyst.
  • For the oxidation of sulfides to sulfones using chromium(VI) oxide catalyst.
  • For the oxidation of naphthalenes and anthracene to quinones using chromium(VI) oxide catalyst.
  • In the synthesis of polyaniline (Pani) by chemical polymerization.
  • N-nitrosation of secondary amines using various heterogeneous catalysts in the presence of Na2NO3.
  • In combination with sodium bisulfate for the preparation iodohydrin substituents by the addition of I-OH to alkenes.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 1: Oxidizing solids
Periodic acid
Hazardous rank I
1st oxidizing solid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

379891-25G:4548173988238
379891-BULK:
379891-VAR:
379891-5G:4548173988221

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCF7603
BCCD1109
BCBV2045
BCBS7595V
BCBS2016V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A. Khazaei, et al.,
Synthesis, 21, 3672-3676 (2009)
Chemical polymerization of aniline using periodic acid in acetonitrile
Muzaffer C, et al.
Synthetic Metals, 159(14), 1486-1490 (2009)
M. Can, et al.,
Synthetic Metals, 159, 1486-1490 (2009)
F. Ruff, et al.,
European Journal of Organic Chemistry, 13, 2102-2111 (2009)
Y. L. Hu, et al.,
Catalysis Communications, 11, 923-927 (2010)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service