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Safety Information

512443

Sigma-Aldrich

3-Chloro-L-tyrosine

97%

Synonym(s):

(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine

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About This Item

Linear Formula:
4-(HO)C6H3(Cl)CH2CH(NH2)CO2H
CAS Number:
7423-93-0
Molecular Weight:
215.63
EC Number:
231-050-3
MDL number:
MFCD00045865
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24873634
NACRES:
NA.22

Quality Level

100

Assay

97%

optical activity

[α]24/D −2°, c = 1 in 1 M HCl

reaction suitability

reaction type: solution phase peptide synthesis

mp

249 °C (lit.)

application(s)

peptide synthesis

SMILES string

N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O

InChI

1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

InChI key

ACWBBAGYTKWBCD-ZETCQYMHSA-N

Related Categories

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

512443-1G:
512443-BULK:
512443-5G:
512443-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT9979
MKCR8685
MKCP5653
MKCJ5561
09001EA

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Eline Thomson et al.
Free radical biology & medicine, 49(9), 1354-1360 (2010-07-22)
We aimed to determine whether myeloperoxidase (MPO) is the main peroxidase present in the airways of children with cystic fibrosis (CF) and to assess which oxidants it produces and whether they are associated with clinical features of CF. Children with
Jihan Talib et al.
Free radical biology & medicine, 53(1), 20-29 (2012-05-23)
Smokers have an elevated risk of atherosclerosis but the origin of this elevated risk is incompletely defined, though increasing evidence supports a role for the oxidant-generating enzyme myeloperoxidase (MPO). In previous studies we have demonstrated that smokers have elevated levels
Laetitia Mouls et al.
Proteomics, 9(6), 1617-1631 (2009-03-03)
Protein oxidation is thought to contribute to a number of inflammatory diseases, hence the development of sensitive and specific analytical techniques to detect oxidative PTMs (oxPTMs) in biological samples is highly desirable. Precursor ion scanning for fragment ions of oxidized
Joseph I Kang et al.
Chemical research in toxicology, 21(5), 1028-1038 (2008-05-03)
While the last 30 years chronicles an extensive effort to understand the damage to DNA caused by reactive oxygen species (ROS), little research has examined the chemical damage to the histone proteins found in chromatin. Hypochlorous acid (HOCl), the primary
Michael Holzer et al.
Antioxidants & redox signaling, 14(12), 2337-2346 (2011-01-18)
Carbamylation of proteins through reactive cyanate has been demonstrated to predict an increased cardiovascular risk. Cyanate is formed in vivo by breakdown of urea and at sites of inflammation by the phagocyte protein myeloperoxidase. Because myeloperoxidase (MPO) associates with high-density
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