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Safety Information

76763

Sigma-Aldrich

1-(4-Pyridyl)piperazine

≥97.0% (GC)

Synonym(s):

4-Piperazinopyridine

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About This Item

Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
1008-91-9
Molecular Weight:
163.22
EC Number:
213-764-7
MDL number:
MFCD00040745
UNSPSC Code:
12352100
PubChem Substance ID:
57652657
NACRES:
NA.22

Quality Level

100

Assay

≥97.0% (GC)

form

powder

impurities

≤1% water

mp

137-141 °C

SMILES string

C1CN(CCN1)c2ccncc2

InChI

1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2

InChI key

OQZBAQXTXNIPRA-UHFFFAOYSA-N

Gene Information

rat ... Chrnb2(54239)

Related Categories

General description

1-(4-Pyridyl) piperazine (or 4-Piperazinopyridine) is an active structural component that is used as a building block to prepare various medicinally important active molecules.

Application

1-(4-Pyridyl) piperazine can be used as a building block for the synthesis of:
  • Nocathiacin I analogs for antibacterial studies.
  • 4-amino-pyridyl derivatives, benzimido isoquinoline based derivatives and tert-pentylphenoxyalkyl piperazine derivatives for various biological applications.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

76763-VAR-F:
76763-BULK-F:
76763-5G-F:
76763-1G-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ6799
BCCF2501
BCBW5372
BCBV9862
BCBT8561

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N ε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure?Activity Relationships, and Pharmacokinetic Profiling.
Wodtke R, et al.
Journal of Medicinal Chemistry, 61(10), 4528-4560 (2018)
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson D M, et al.
Journal of Medicinal Chemistry, 48(6), 1857-1872 (2005)
Identification of ML204: a novel potent antagonist that selectively modulates native TRPC4/C5 channels.
Miller M, et al.
The Journal of Biological Chemistry, jbc-M111 (2011)
Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands.
Szczepanska K, et al.
European Journal of Medicinal Chemistry, 152, 223-234 (2018)
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics
Naidu BN, et al.
Bioorganic & Medicinal Chemistry, 14(22), 5573-5577 (2004)
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