Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

Safety Information

804401

Sigma-Aldrich

PyFluor

Synonym(s):

2-Pyridinesulfonyl Fluoride

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C5H4FNO2S
CAS Number:
878376-35-3
Molecular Weight:
161.15
MDL number:
MFCD09265513
UNSPSC Code:
12352101
PubChem Substance ID:
329768867
NACRES:
NA.22

Assay

95% (HPLC)

Quality Level

100

form

solid

mp

29-34 °C

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC=N1)(F)=O

InChI

1S/C5H4FNO2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H

InChI key

FCFXLXGZHDHJLB-UHFFFAOYSA-N

Application

2-pyridinesulfonyl fluoride can be used for the deoxyfluorination of primary and secondary alcohols in combination with an amidine or guanidine base. In comparison with other common deoxyfluorination reagents, for example, DAST exhibits less elimination side products in direct comparison on certain substrates.

Legal Information

PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

804401-VAR:
804401-5G:
804401-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCW7067
MKCS8346
MKCR2767
MKCQ1036
MKCN2100

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.

Related Content

Doyle Group – Prof. Product Portal

Doyle group focuses on nucleophilic fluorination using PyFluor and nickel catalysis with modular, air-stable nickel precatalyst.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service