900864

4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

• Synonym(s): Bromo sulfonyl fluoride TMS-alkyne, Probe building block
• Empirical Formula (Hill Notation): C₁₂H₁₄BrFO₂SSi
• CAS Number: 2088828-99-1
• Molecular Weight: 349.29
• MDL number: MFCD31625432
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder or crystals
• availability: available only in USA
• storage temp.: −20°C
• SMILES string: O=S(C(C(C#C[Si](C)(C)C)=C1)=CC=C1CBr)(F)=O
• InChI: 1S/C12H14BrFO2SSi/c1-18(2,3)7-6-11-8-10(9-13)4-5-12(11)17(14,15)16/h4-5,8H,9H2,1-3H3
• InChI key: WFOCWDDRVBJLGX-UHFFFAOYSA-N

Description

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

• 1.Technology Spotlight: Trifunctional Probe Building Blocks
• 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H242
• Precautionary Statements: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable