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Safety Information

905283

Sigma-Aldrich

(6-Aminohexyl)triphenylphosphonium bromide hydrobromide

≥95%

Synonym(s):

Aminohexane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag

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About This Item

Empirical Formula (Hill Notation):
C24H29BrNP · xHBr
Molecular Weight:
442.37 (free base basis)
UNSPSC Code:
12352101
NACRES:
NA.22

Assay

≥95%

form

solid

reaction suitability

reagent type: ligand

functional group

phosphine

storage temp.

2-8°C

Related Categories

Application

Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship. This aminohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.

Other Notes

Development of organelle-targetable europium complex probes for time-gated luminescence imaging of hypochlorous acid in live cells and animals

Targeting lipophilic cations to mitochondria

Photoswitchable polyfluorophores based on perylenemonoimide-dithienylethene conjugates as super-resolution MitoTrackers

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

905283-BULK:
905283-1G:
905283-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000238155
0000189804
MKCK4909

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Michael P Murphy
Biochimica et biophysica acta, 1777(7-8), 1028-1031 (2008-04-29)
Mitochondrial function and dysfunction contributes to a range of important aspects of biomedical research. Consequently there is considerable interest in developing approaches to modify and report on mitochondria in cells and in vivo. One approach has been to target bioactive

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