Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

Safety Information

919012

Sigma-Aldrich

PEI Prime™ linear polyethylenimine

suitable for gene delivery

Synonym(s):

PEI

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Linear Formula:
(C2H5N . HCl)n
CAS Number:
49553-93-7
MDL number:
MFCD00009361
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

powder

color

white to off-white

storage temp.

2-8°C

SMILES string

N(CCC)C

InChI

1S/C4H11N/c1-3-4-5-2/h5H,3-4H2,1-2H3

InChI key

GVWISOJSERXQBM-UHFFFAOYSA-N

Application

PEI Prime™ is a cationic polymer designed for high-yield, reproducible and scalable drug and gene delivery. As a gene carrier, PEI forms a complex with nucleic acids via electrostatic self-assembly between the negatively charged nucleic acid phosphate groups and positively charged PEI amine groups. Due to this interaction, PEI has been extensively explored as a gene carrier and is one of the most effective synthetic polymers for the delivery of nucleic acids into cells through endocytosis.


PEI Prime™ uses an optimized form of PEI to reduce performance variance and speed process development time. Each batch of PEI Prime™ undergoes triplicate, quantitative performance testing using an SEAP reporter assay. PEI Prime™ is an excellent choice to produce any biologic cost-effectively, including recombinant proteins, antibodies, and viruses.

Legal Information

PEI Prime is a trademark of Serochem LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

919012-100MG:
919012-500MG:
919012-VAR:
919012-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCW4935
MKCV6751
MKCT5539
MKCT0529
MKCV0804

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

S M Zou et al.
The journal of gene medicine, 2(2), 128-134 (2000-05-16)
Several nonviral vectors including linear polyethylenimine (L-PEI) confer a pronounced lung tropism to plasmid DNA when injected into the mouse tail vein in a nonionic solution. and results We have optimized this route by injecting 50 microg DNA with excess
W T Godbey et al.
Biomaterials, 22(5), 471-480 (2001-02-24)
Poly(ethylenimine) (PEI) was used to transfect the endothelial cell line EA.hy 926, and the secreted levels of three gene products, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand Factor (vWF), were assessed via ELISA. We
L Wightman et al.
The journal of gene medicine, 3(4), 362-372 (2001-09-01)
Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Linear or branched polyethylenimine (PEI)/DNA complexes were generated in varying

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service