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Merck
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Key Documents

Safety Information

919926

Sigma-Aldrich

TissueFab® bioink 

Crosslinking solution, low endotoxin

Synonym(s):

Calcium chloride solution

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

description

suitable for 3D bioprinting applications

sterility

sterile-filtered

form

viscous liquid

impurities

≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden (Total Aerobic)
<25 EU/mL Endotoxin

color

colorless to light yellow

particle size

0.1 μm

pH

6.5-7.5

application(s)

3D bioprinting

storage temp.

2-8°C

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Application

TissueFab® - crosslinking solution is 200 mM calcium chloride solution, it is a crosslinking agent for chemical crosslinking of bioinks that contain alginate. Alginate is a naturally occurring anionic polymer typically obtained from brown seaweed, and has been extensively in bioink formulations, due to its biocompatibility, structural similarity with extracellular matrix of living tissues, and mild gelation. The sodium salt of alginic acid can be crosslinked by exposing to the crosslinker solution containing divalent Ca2+ cation.

Packaging

5 x 10ml case pack

Legal Information

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

919926-BULK:
919926-1EA:
919926-VAR:

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Wee et al.
Advanced drug delivery reviews, 31(3), 267-285 (2000-06-06)
There are a variety of both natural and synthetic polymeric systems that have been investigated for the controlled release of proteins. Many of the procedures employed to incorporate proteins into a polymeric matrix can be harsh and often cause denaturation
Kuen Yong Lee et al.
Progress in polymer science, 37(1), 106-126 (2011-11-30)
Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications

Articles

Bioink Selection for 3D Bioprinting

Bioinks enable 3D bioprinting of tissue constructs for drug screening and transplantation; select suitable bioinks for specific tissue engineering.

Recent Advances in 3D-Bioprinting-based Drug Screening

Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.

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