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930067

Sigma-Aldrich

2-(Pyrimidin-5-yl)benzaldehyde

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About This Item

Empirical Formula (Hill Notation):
C11H9N2O
Molecular Weight:
185.20
MDL number:
MFCD02684096
UNSPSC Code:
12352101
NACRES:
NA.06

form

powder or chunks

Quality Level

100

mp

119-120 °C

functional group

aldehyde

storage temp.

−20°C

SMILES string

n1cncc(c1)c2c(cccc2)C=O

InChI

1S/C11H8N2O/c14-7-9-3-1-2-4-11(9)10-5-12-8-13-6-10/h1-8H

InChI key

JPSJBEALHNYNBL-UHFFFAOYSA-N

Related Categories

Application

2-(Pyrimidin-5-yl)benzaldehyde is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-(pyrimidin-5-yl)benzaldehyde is an effective TDG for meta directed C-H functionalization of amine substituted target compounds, with high selectivity.

Other Notes

Imine as a linchpin approach for meta-C–H functionalization

https://www.nature.com/articles/s41570-021-00311-3">Transient directing ligands for selective metal-catalysed C–H activation

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Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

930067-BULK:
930067-1G:
930067-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS2135

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Transient directing ligands for selective metal-catalysed C?H activation
Nupur, et al.
Nature Reviews Chemistry, 5, 646?659-646?659 (2021)
Sukdev Bag et al.
Nature communications, 12(1), 1393-1393 (2021-03-04)
Despite the widespread applications of C-H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing groups (DGs) served as ancillary ligands to ensure ortho-, meta- and para-C-H functionalization over the last two decades. These covalently linked DGs necessitate

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